SAC - Sociedad Andaluza de Cancerología
 
SAC - Sociedad Andaluza de Cancerología
 
 

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ASTRO Guideline on Postoperative Radiation Therapy for Endometrial Cancer
25 de Abril de 2014
Purpose: To present evidence-based guidelines for adjuvant radiation in the treatment of endometrial cancer.
Methods and materials: Key clinical questions to be addressed in this evidence-based guideline on endometrial cancer were identified. A comprehensive literature review was performed to identify studies that included no adjuvant therapy, or pelvic radiation or vaginal brachytherapy with or without systemic chemotherapy. Outcomes included local control, survival rates, and overall assessment of quality of life.
Results: Patients with grade 1 or 2 cancers with either no invasion or b50% myometrial invasion (MI), especially when no other high risk features are present, can be safely observed after hysterectomy. Vaginal cuff brachytherapy is as effective as pelvic radiation therapy at preventing vaginal recurrence for patients with grade 1 or 2 cancers with ≥50% MI or grade 3 tumors with 50% MI. Patients with grade 3 cancer with ≥50% MI or cervical stroma invasion may benefit from pelvic radiation to reduce the risk of pelvic recurrence. There is limited evidence for a benefit to vaginal cuff brachytherapy following pelvic radiation. Multimodality treatment is recommended for patients with positive nodes or involved uterine serosa, ovaries or fallopian tubes, vagina, bladder, or rectum.
Conclusions: External beam and vaginal brachytherapy remain integral aspects of adjuvant therapy for endometrial cancer.
  Documentos relacionados.
ASTRO Guideline on Postoperative Radiation Therapy for Endometrial Cancer.
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ASTRO Guideline on Postoperative Radiation Therapy for Endometrial Cancer.
 
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